Mary Cushman

Mary Louise Cushman, age 31, Alvarado, TX View Details

Cities: Jensen Beach FL, Davenport FL Possible Relatives: Dean J Moniz

Mary M Cushman, age 86, Tarentum, PA View Details

Cities: Jensen Beach FL, Davenport FL

Mary L Cushman, age 51 View Details

Address:***** Manor Ave, Allen Park, MI. Phone Number: (313) 215-****

Mary A Cushman, age 59 View Details

Address:***** Sunset Way, Sonoma, CA. Phone Number: (707) 996-****

Mary Virginia Cushman, age 50s, Indianapolis, IN View Details

Locations: Indianapolis IN, Summerville SC Possible Relatives: Ann Cushman, Luann Ann Cushman

Mary Ellen Cushman, age 50s, Longmont, CO View Details

Locations: Longmont CO, Estes Park CO, Westminster CO Possible Relatives: Jose M Baquerizo, Ellen Mae Cushman

Mary V Cushman, age 58, San Diego, CA View Details

Cities: San Diego CA, Coronado CA

Mary L Cushman, age 72 View Details

Possible Relatives: Cressan Mitchell Cushman, Diana Lorene Cushman, Gary Preston Cushman

Mark Cushman

Mark S. Cushman is an American chemist, whose primary research is in the area of medicinal chemistry. He completed his pre-pharmacy studies at Fresno State College (now California State University, Frread more...esno) in 1965. He then attended the University of California San Francisco (as a University of California Regents Scholar), earning a Pharm.D. in 1969 and a Ph.D. in Medicinal Chemistry in 1973. Thereafter, he performed postdoctoral training in the laboratory of George Büchi, Ph.D., at the Massachusetts Institute of Technology (MIT). There, his research focused on the discovery and development of new synthetic methodologies, and the isolation and structural characterization of mycotoxins from Aspergillus niger. In 1975, he joined the Department of Medicinal Chemistry and Molecular Pharmacology (at the time, Department of Medicinal Chemistry and Pharmacognosy) at Purdue University. From 1983 to 1984, Prof. Cushman was a Senior Fulbright Scholar at Munich Technical University working in the laboratory of Professor Adelbert Bacher. His sabbatical work dealt with the design and synthesis of probes to elucidate key aspects of the biosynthesis of riboflavin (vitamin B2). Currently he holds the rank of Distinguished Professor Emeritus of Medicinal Chemistry at Purdue University. He has mentored 40 graduate students, 59 postdoctoral researchers, and 5 visiting scholars. He has published 348 papers and holds 41 patents. His work has ~17,000 citations with an h-index of 69. His most cited papers had 471, 403, and 299 citations as of August 2021. He has made seminal contributions to the fields of synthetic and medicinal chemistry including the development of new synthetic methodologies, the synthesis of natural products, and the preparation of antivirals, antibacterials, and anticancer agents, and mechanism probes to understand the function of over thirty macromolecular targets. One of his main scientific contributions is the development of the indenoisoquinolines, molecules that inhibit the action of toposiomerase I (Top1) and stabilize the G-quadruplex in the Myc promoter. Three indenoisoquinolines designed and synthesized by his research group at Purdue University [indotecan (LMP 400), indimitecan (LMP 776), and LMP 744] demonstrated potent anticancer activity in vivo and have completed phase I clinical trials at the National Institutes of Health.read less...

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